Background: Atopic Dermatitis (AD) is a common skin disorder affecting 12-15% of all children in early childhood. Prevalence of AD is reported to have increased over the 3 decades. The impact is not limited to the child but extends to the entire family.Method: Parents of 40 infants and children with AD (based on Hanifin & Rajka) and 40 infants or children without any chronic disease participated in this study and a physician filled Family Dermatitis Index (FDI) questionnaire for them via face to face interview. The mean total score of each questionnaire in cases and controls were compared by t-test and correlate with severity of AD.Results: The mean diagnose age of AD was 1.57±0.53 years (4 months to 4 years) and the mean±SD score for FDI was 13.17±4.49. For the control group, the mean age of their children was 2.68±1.32 years and the mean±SD score for the FDI was 1.05±1.19. The difference between the mean of FDI in control and patients groups was also significantly different (p<0.001). The correlation between the FDI with severity of AD was significant.Conclusion: AD is a common skin disease that places a large burden on patients, their families, and the society. We can detect the severity of AD directly related to the high impact of AD on their parent̉ s lives. It should be suggested that education and psychosocial support for targeting parents and caregivers that may decrease family and personal burden and improve the long-term physical outcomes.